InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IRF3

Summary

InnateDB Protein

IDBP-765596.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IRF3

Protein Name

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000471896

InnateDB Gene

IDBG-63225 (IRF3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 156 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	156 [view]
Protein-Protein	105 [view]
Protein-DNA	51 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000975	regulatory region DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003712	transcription cofactor activity
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0002224	toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006915	apoptotic process
GO:0006974	cellular response to DNA damage stimulus
GO:0009617	response to bacterium
GO:0016032	viral process
GO:0019221	cytokine-mediated signaling pathway
GO:0031663	lipopolysaccharide-mediated signaling pathway
GO:0032480	negative regulation of type I interferon production
GO:0032481	positive regulation of type I interferon production
GO:0032496	response to lipopolysaccharide
GO:0032727	positive regulation of interferon-alpha production
GO:0032728	positive regulation of interferon-beta production
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0035666	TRIF-dependent toll-like receptor signaling pathway
GO:0039530	MDA-5 signaling pathway
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043330	response to exogenous dsRNA
GO:0045087	innate immune response (InnateDB)
GO:0045351	type I interferon biosynthetic process
GO:0045358	negative regulation of interferon-beta biosynthetic process
GO:0050689	negative regulation of defense response to virus by host
GO:0050715	positive regulation of cytokine secretion
GO:0051607	defense response to virus
GO:0060333	interferon-gamma-mediated signaling pathway
GO:0060337	type I interferon signaling pathway
GO:0060340	positive regulation of type I interferon-mediated signaling pathway
GO:0071359	cellular response to dsRNA
GO:0071888	macrophage apoptotic process
GO:0097300	programmed necrotic cell death