Version 5.4
Bos taurus Protein: BT.45349
Summary
InnateDB Protein IDBP-692233.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.45349
Protein Name mitochondrial antiviral-signaling protein
Synonyms VISA;
Species Bos taurus
Ensembl Protein ENSBTAP00000018013
InnateDB Gene IDBG-640031 (BT.45349)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 90 interaction(s) predicted by orthology.
Predicted by orthology
Total 90 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0050700 CARD domain binding
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0002218 activation of innate immune response
GO:0002230 positive regulation of defense response to virus by host
GO:0007165 signal transduction
GO:0032481 positive regulation of type I interferon production
GO:0032727 positive regulation of interferon-alpha production
GO:0032728 positive regulation of interferon-beta production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0033160 positive regulation of protein import into nucleus, translocation
GO:0039529 RIG-I signaling pathway
GO:0042742 defense response to bacterium
GO:0042993 positive regulation of transcription factor import into nucleus
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045071 negative regulation of viral genome replication
GO:0045087 innate immune response
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051607 defense response to virus
GO:0060340 positive regulation of type I interferon-mediated signaling pathway
GO:0071360 cellular response to exogenous dsRNA
GO:0071651 positive regulation of chemokine (C-C motif) ligand 5 production
GO:0071660 positive regulation of IP-10 production
GO:1900063 regulation of peroxisome organization
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005777 peroxisome
GO:0005778 peroxisomal membrane
GO:0031966 mitochondrial membrane
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q1KLR4
UniProt Splice Variant
Entrez Gene 618508
UniGene Bt.45349
RefSeq NP_001040085
HUGO HGNC:29233
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02036176 DAAA02036177 DQ471979
GenPept ABF13431

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca