Homo sapiens Protein: MAVS
InnateDB Protein IDBP-364593.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAVS
Protein Name mitochondrial antiviral signaling protein
Species Homo sapiens
Ensembl Protein ENSP00000401980
InnateDB Gene IDBG-49080 (MAVS)
Protein Structure
UniProt Annotation
Function Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon- independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon- dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis. {ECO:0000269PubMed:16125763, ECO:0000269PubMed:16127453, ECO:0000269PubMed:16153868, ECO:0000269PubMed:16177806, ECO:0000269PubMed:19631370, ECO:0000269PubMed:20451243}.
Subcellular Localization Mitochondrion outer membrane. Mitochondrion. Peroxisome.
Disease Associations
Tissue Specificity Present in T-cells, monocytes, epithelial cells and hepatocytes (at protein level). Ubiquitously expressed, with highest levels in heart, skeletal muscle, liver, placenta and peripheral blood leukocytes. {ECO:0000269PubMed:16125763, ECO:0000269PubMed:16127453, ECO:0000269PubMed:16153868}.
Number of Interactions This gene and/or its encoded proteins are associated with 156 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 156 [view]
Protein-Protein 156 [view]
Protein-DNA 0
Protein-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0050700 CARD domain binding
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0002218 activation of innate immune response
GO:0002230 positive regulation of defense response to virus by host
GO:0007165 signal transduction
GO:0016032 viral process
GO:0032480 negative regulation of type I interferon production
GO:0032481 positive regulation of type I interferon production
GO:0032727 positive regulation of interferon-alpha production
GO:0032728 positive regulation of interferon-beta production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0033160 positive regulation of protein import into nucleus, translocation
GO:0039529 RIG-I signaling pathway
GO:0042742 defense response to bacterium
GO:0042993 positive regulation of transcription factor import into nucleus
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045071 negative regulation of viral genome replication
GO:0045087 innate immune response (InnateDB)
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051607 defense response to virus
GO:0060340 positive regulation of type I interferon-mediated signaling pathway
GO:0071360 cellular response to exogenous dsRNA
GO:0071651 positive regulation of chemokine (C-C motif) ligand 5 production
GO:0071660 positive regulation of IP-10 production
GO:1900063 regulation of peroxisome organization
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005777 peroxisome
GO:0005778 peroxisomal membrane
GO:0016021 integral component of membrane
GO:0031966 mitochondrial membrane
Protein Structure and Domains
Post-translational Modifications
SwissProt Q7Z434
PhosphoSite PhosphoSite-Q7Z434
UniProt Splice Variant
Entrez Gene 57506
UniGene Hs.570362
RefSeq NP_065797
OMIM 609676
HPRD 13847
EMBL AB033097 AB097003 AB232371 AK023799 AK123956 AK130992 AK291785 AK296897 AL109804 AL353194 BC044952 CH471133 DQ167126 DQ174270 DQ181928 EF467323 EF467324 KC415005
GenPept AAH44952 AAZ80417 ABA19229 ABA54890 ABR24161 ABR24162 AGF94754 BAA86585 BAB14684 BAC77356 BAC85473 BAC85734 BAE79738 BAF84474 BAG59455 CAI11041 CAI18851 EAX10481