InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GPR77

Summary

InnateDB Gene

IDBG-59470.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPR77

Gene Name

G protein-coupled receptor 77

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000134830

Encoded Proteins

IDBP-764384

IDBP-765483

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21630250

GPR77 is an alternate receptor for C5a and is negatively regulated by the TLR-signalling pathway. TLR-mediated inhibition of GPR77 results in the amplification of complement pro-inflammatory responses. (Demonstrated in murine model)

InnateDB Annotation from Orthologs

Summary

PMID 21630250

[Mus musculus] Gpr77 is an alternate receptor for C5a and is negatively regulated by the TLR-signalling pathway. TLR-mediated inhibition of Gpr77 results in the amplification of complement pro-inflammatory responses.

Entrez Gene

Summary

This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:47332147-47347327

Strand

Forward strand

Band

q13.32

Transcripts

ENST00000600626	ENSP00000471184
ENST00000595464	ENSP00000472620

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004944	C5a anaphylatoxin receptor activity
GO:0005515	protein binding

Biological Process

GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0032720	negative regulation of tumor necrosis factor production
GO:0045087	innate immune response (InnateDB)
GO:0050679	positive regulation of epithelial cell proliferation
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0090024	negative regulation of neutrophil chemotaxis
GO:1900165	negative regulation of interleukin-6 secretion
GO:2000482	regulation of interleukin-8 secretion

Cellular Component

GO:0005886	plasma membrane
GO:0009925	basal plasma membrane
GO:0016021	integral component of membrane
GO:0045177	apical part of cell

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000074361

View Gene Order

ENSBTAG00000037735

Not yet available

Pathways

NETPATH

REACTOME

REACT_14819

Peptide ligand-binding receptors pathway

REACT_14828

Class A/1 (Rhodopsin-like receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_21340

GPCR ligand binding pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q9P296

TrEMBL

UniProt Splice Variant

Entrez Gene

27202

UniGene

Hs.534412

RefSeq

NM_001271749 NM_001271750 NM_018485

HUGO

HGNC:4527

OMIM

609949

CCDS

CCDS12699

HPRD

17072

IMGT

EMBL

AB038237 AC008754 AF317655 AK313994 AY268430 BC067478 CH471126

GenPept

AAH67478 AAK12640 AAP23197 BAA95414 BAG36706 EAW57472

RNA Seq Atlas

27202