Version 5.4
Bos taurus Protein: AP3B1
Summary
InnateDB Protein IDBP-697887.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AP3B1
Protein Name AP-3 complex subunit beta-1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000006605
InnateDB Gene IDBG-645194 (AP3B1)
Protein Structure
UniProt Annotation
Function Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Golgi apparatus {ECO:0000250}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0019903 protein phosphatase binding
GO:0030742 GTP-dependent protein binding
Biological Process
GO:0006622 protein targeting to lysosome
GO:0006810 transport
GO:0006886 intracellular protein transport
GO:0007596 blood coagulation
GO:0008089 anterograde axon cargo transport
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0019882 antigen processing and presentation
GO:0032438 melanosome organization
GO:0048007 antigen processing and presentation, exogenous lipid antigen via MHC class Ib
GO:0048490 anterograde synaptic vesicle transport
GO:0051138 positive regulation of NK T cell differentiation
Cellular Component
GO:0005765 lysosomal membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0030117 membrane coat
GO:0030123 AP-3 adaptor complex
GO:0030665 clathrin-coated vesicle membrane
GO:0031410 cytoplasmic vesicle
Protein Structure and Domains
PDB ID
InterPro IPR002553 Clathrin/coatomer adaptor, adaptin-like, N-terminal
IPR016024 Armadillo-type fold
IPR026740 AP-3 complex subunit beta
PFAM PF01602
PRINTS
PIRSF PIRSF037096
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q32PG1
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 767602
UniGene Bt.87772
RefSeq NP_001070002
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC108129
GenPept AAI08130

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca