Homo sapiens Protein: DDX58 | |||||||||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||||||||
InnateDB Protein | IDBP-55856.6 | ||||||||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||
Gene Symbol | DDX58 | ||||||||||||||||||||||||||||||||||
Protein Name | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | ||||||||||||||||||||||||||||||||||
Synonyms | RIG-I; RIGI; RLR-1; | ||||||||||||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||||||||||||
Ensembl Protein | ENSP00000369213 | ||||||||||||||||||||||||||||||||||
InnateDB Gene | IDBG-55854 (DDX58) | ||||||||||||||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||||||||||||||
Function | Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include: 5'- triphosphorylated ssRNA and dsRNA and short dsRNA (<1 kb in length). In addition to the 5'-triphosphate moiety, blunt-end base pairing at the 5'-end of the RNA is very essential. Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impact on its activity. A 3'overhang at the 5'triphosphate end decreases and any 5'overhang at the 5' triphosphate end abolishes its activity. Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK- related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Detects both positive and negative strand RNA viruses including members of the families Paramyxoviridae: Human respiratory syncytial virus and measles virus (MeV), Rhabdoviridae: vesicular stomatitis virus (VSV), Orthomyxoviridae: influenza A and B virus, Flaviviridae: Japanese encephalitis virus (JEV), hepatitis C virus (HCV), dengue virus (DENV) and west Nile virus (WNV). It also detects rotavirus and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome such as Epstein-Barr virus (EBV). Detects dsRNA produced from non-self dsDNA by RNA polymerase III, such as Epstein-Barr virus-encoded RNAs (EBERs). May play important roles in granulocyte production and differentiation, bacterial phagocytosis and in the regulation of cell migration. {ECO:0000269PubMed:15208624, ECO:0000269PubMed:15708988, ECO:0000269PubMed:16125763, ECO:0000269PubMed:16127453, ECO:0000269PubMed:16153868, ECO:0000269PubMed:17190814, ECO:0000269PubMed:18636086, ECO:0000269PubMed:19122199, ECO:0000269PubMed:19211564, ECO:0000269PubMed:19576794, ECO:0000269PubMed:19609254, ECO:0000269PubMed:19631370, ECO:0000269PubMed:21742966}. | ||||||||||||||||||||||||||||||||||
Subcellular Localization | Cytoplasm. Cell projection, ruffle membrane. Cytoplasm, cytoskeleton. Cell junction, tight junction. Note=Colocalized with TRIM25 at cytoplasmic perinuclear bodies. Associated with the actin cytoskeleton at membrane ruffles. | ||||||||||||||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||||||||||||||
Tissue Specificity | Present in vascular smooth cells (at protein level). {ECO:0000269PubMed:15219805}. | ||||||||||||||||||||||||||||||||||
Comments | |||||||||||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 119 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||||||||||||||
InterPro |
IPR001650
Helicase, C-terminal IPR006935 Helicase/UvrB domain IPR011029 Death-like domain IPR011545 DEAD/DEAH box helicase domain IPR014001 Helicase, superfamily 1/2, ATP-binding domain IPR021673 C-terminal domain of RIG-I IPR027417 P-loop containing nucleoside triphosphate hydrolase |
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PFAM |
PF00271
PF04851 PF00270 PF11648 |
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PRINTS | |||||||||||||||||||||||||||||||||||
PIRSF | |||||||||||||||||||||||||||||||||||
SMART |
SM00490
SM00487 |
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TIGRFAMs | |||||||||||||||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||||||||||||||
Modification | |||||||||||||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||||||||||||
SwissProt | O95786 | ||||||||||||||||||||||||||||||||||
PhosphoSite | PhosphoSite-O95786 | ||||||||||||||||||||||||||||||||||
TrEMBL | A2A376 | ||||||||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||||||||
Entrez Gene | 23586 | ||||||||||||||||||||||||||||||||||
UniGene | Hs.609798 | ||||||||||||||||||||||||||||||||||
RefSeq | NP_055129 | ||||||||||||||||||||||||||||||||||
HUGO | HGNC:19102 | ||||||||||||||||||||||||||||||||||
OMIM | 609631 | ||||||||||||||||||||||||||||||||||
CCDS | CCDS6526 | ||||||||||||||||||||||||||||||||||
HPRD | 13131 | ||||||||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||||||||
EMBL | AF038963 AL137608 AL161783 AL353671 BC132786 BC136610 BX647917 CH471071 | ||||||||||||||||||||||||||||||||||
GenPept | AAD19826 AAI32787 AAI36611 CAB70840 CAH71251 CAH72600 CAI46068 EAW58548 | ||||||||||||||||||||||||||||||||||