InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MED14

Summary

InnateDB Gene

IDBG-57018.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MED14

Gene Name

mediator complex subunit 14

Synonyms

CRSP150; CRSP2; CSRP; CXorf4; DRIP150; EXLM1; RGR1; TRAP170

Species

Homo sapiens

Ensembl Gene

ENSG00000180182

Encoded Proteins

IDBP-57020

mediator complex subunit 14

IDBP-367604

mediator complex subunit 14

IDBP-367605

mediator complex subunit 14

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:40648306-40735858

Strand

Reverse strand

Band

p11.4

Transcripts

ENST00000324817	ENSP00000323720
ENST00000416199	ENSP00000392586
ENST00000433003	ENSP00000411357
ENST00000472736
ENST00000496531
ENST00000482034
ENST00000492219
ENST00000495865
ENST00000463072

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 88 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	88 [view]
Protein-Protein	83 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001104	RNA polymerase II transcription cofactor activity
GO:0003712	transcription cofactor activity
GO:0003713	transcription coactivator activity
GO:0004872	receptor activity
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
GO:0042809	vitamin D receptor binding
GO:0046966	thyroid hormone receptor binding

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0010467	gene expression
GO:0019827	stem cell maintenance
GO:0030518	intracellular steroid hormone receptor signaling pathway
GO:0030521	androgen receptor signaling pathway
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter