Version 5.4
Homo sapiens Gene: CHD3
Summary
InnateDB Gene IDBG-27053.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHD3
Gene Name chromodomain helicase DNA binding protein 3
Synonyms Mi-2a; Mi2-ALPHA; ZFH
Species Homo sapiens
Ensembl Gene ENSG00000170004
Encoded Proteins
IDBP-27055
chromodomain helicase DNA binding protein 3
IDBP-27057
chromodomain helicase DNA binding protein 3
IDBP-27059
chromodomain helicase DNA binding protein 3
IDBP-366897
chromodomain helicase DNA binding protein 3
IDBP-366901
chromodomain helicase DNA binding protein 3
IDBP-366902
chromodomain helicase DNA binding protein 3
IDBP-760124
IDBP-763191
IDBP-758625
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:7884806-7912760
Strand Forward strand
Band p13.1
Transcripts
ENST00000380358 ENSP00000369716
ENST00000330494 ENSP00000332628
ENST00000358181 ENSP00000350907
ENST00000452447 ENSP00000405861
ENST00000439235 ENSP00000395252
ENST00000449744 ENSP00000411959
ENST00000479080
ENST00000470531 ENSP00000467547
ENST00000466233
ENST00000473376
ENST00000481999
ENST00000573936 ENSP00000459321
ENST00000574022
ENST00000572750
ENST00000571249 ENSP00000458861
ENST00000570758
ENST00000572579
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 190 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 190 [view]
Protein-Protein 189 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004003 ATP-dependent DNA helicase activity
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006200 ATP catabolic process
GO:0006325 chromatin organization
GO:0006333 chromatin assembly or disassembly
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007051 spindle organization
GO:0008152 metabolic process
GO:0016568 chromatin modification
GO:0032508 DNA duplex unwinding
GO:0051297 centrosome organization
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0016581 NuRD complex
GO:0045111 intermediate filament cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000018474
View Gene Order
ENSBTAG00000014377
Not yet available
Pathways
NETPATH
REACTOME
REACT_953
RNA Polymerase I Transcription Initiation pathway
REACT_1309
RNA Polymerase I Transcription pathway
REACT_1974
RNA Polymerase I Promoter Clearance pathway
REACT_228222
HDACs deacetylate histones pathway
REACT_172623
Chromatin organization pathway
REACT_172633
Chromatin modifying enzymes pathway
REACT_21352
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
hdac_classi_pathway
Signaling events mediated by HDAC Class I
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.25601 Hs.706339
RefSeq NM_001005271 NM_001005273 NM_005852 XM_005256429 XM_005256431 XM_006721428 XM_006721429 XM_006721430
HUGO
OMIM
CCDS CCDS32553 CCDS32554 CCDS32555
HPRD 09071
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca